The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway

• Main Authors: Weimin Yu (Author), Gang Xu (Author), Hui Chen (Author), Li Xiao (Author), Gang Liu (Author), Pingping Hu (Author), Siqi Li (Author), Vivi Kasim (Author), Chunyu Zeng (Author), Xiaoyong Tong (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role. The cysteine 674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is...