The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway

• Autors principals: Weimin Yu (Autor), Gang Xu (Autor), Hui Chen (Autor), Li Xiao (Autor), Gang Liu (Autor), Pingping Hu (Autor), Siqi Li (Autor), Vivi Kasim (Autor), Chunyu Zeng (Autor), Xiaoyong Tong (Autor)
• Format: Llibre
• Publicat: Elsevier, 2022-05-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role. The cysteine 674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is...