Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.

• Main Authors: Ryuichi Miura (Author), Takanori Kooriyama (Author), Misako Yoneda (Author), Akiko Takenaka (Author), Miho Doki (Author), Yasuyuki Goto (Author), Chizu Sanjoba (Author), Yasuyuki Endo (Author), Tomoko Fujiyuki (Author), Akihiro Sugai (Author), Kyoko Tsukiyama-Kohara (Author), Yoshitsugu Matsumoto (Author), Hiroki Sato (Author), Chieko Kai (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Canine distemper virus (CDV) vaccination confers long-term protection against CDV reinfection. To investigate the utility of CDV as a polyvalent vaccine vector for Leishmania, we generated recombinant CDVs, based on an avirulent Yanaka strain, that expressed Leishmania antigens: LACK, TSA, or LmSTI1...