Oxostephanine, Thalmiculine, and Thaliphyline-Three Isoquinoleine Alkaloids That Inhibit L-Type Voltage-Gated Ca²⁺ Channels

• Main Authors: Jacinthe Frangieh (Author), Claire Legendre (Author), Dimitri Bréard (Author), Pascal Richomme (Author), Daniel Henrion (Author), Ziad Fajloun (Author), César Mattei (Author), Anne-Marie Le Ray (Author), Christian Legros (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The isoquinoline alkaloids (IAs) represent a large and diverse subfamily of phytochemicals in terms of structures and pharmacological activities, including ion channel inhibition. Several IAs, such as liriodenine (an oxoaporphine) and curine (a bisbenzylisoquinoline (BBIQ), inhibit the L-type voltag...