Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell-Derived Cardiomyocyte Sheet: Multi-site Validation Study

• Egile Nagusiak: Yuji Nakamura (Egilea), Junko Matsuo (Egilea), Norimasa Miyamoto (Egilea), Atsuko Ojima (Egilea), Kentaro Ando (Egilea), Yasunari Kanda (Egilea), Kohei Sawada (Egilea), Atsushi Sugiyama (Egilea), Yuko Sekino (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2014-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A prospective comparison study across 3 independent research laboratories of a pure IKr blocker E-4031 was conducted by using the same batch of human iPS cell-derived cardiomyocytes in order to verify the utility and reliability of our original standard protocol. Field potential waveforms were recor...