Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell-Derived Cardiomyocyte Sheet: Multi-site Validation Study

• Main Authors: Yuji Nakamura (Author), Junko Matsuo (Author), Norimasa Miyamoto (Author), Atsuko Ojima (Author), Kentaro Ando (Author), Yasunari Kanda (Author), Kohei Sawada (Author), Atsushi Sugiyama (Author), Yuko Sekino (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A prospective comparison study across 3 independent research laboratories of a pure IKr blocker E-4031 was conducted by using the same batch of human iPS cell-derived cardiomyocytes in order to verify the utility and reliability of our original standard protocol. Field potential waveforms were recor...