A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus.

• Main Authors: Stephen D S McCarthy (Author), Beata Majchrzak-Kita (Author), Trina Racine (Author), Hannah N Kozlowski (Author), Darren P Baker (Author), Thomas Hoenen (Author), Gary P Kobinger (Author), Eleanor N Fish (Author), Donald R Branch (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Fag: article
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To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in vitro and/or in non-human primate studies, differences in experimental methodologies make it difficult to compare their therapeutic effective...