Antiangiogenic and antitumor effects of Trypanosoma cruzi Calreticulin.

• Main Authors: Nandy C López (Author), Carolina Valck (Author), Galia Ramírez (Author), Margarita Rodríguez (Author), Carolina Ribeiro (Author), Juana Orellana (Author), Ismael Maldonado (Author), Adriana Albini (Author), Daniel Anacona (Author), David Lemus (Author), Lorena Aguilar (Author), Wilhelm Schwaeble (Author), Arturo Ferreira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: In Latin America, 18 million people are infected with Trypanosoma cruzi, the agent of Chagas' disease, with the greatest economic burden. Vertebrate calreticulins (CRT) are multifunctional, intra- and extracellular proteins. In the endoplasmic reticulum (ER) they bind calcium and ac...