Improving the tumor selectivity of T cell engagers by logic-gated dual tumor-targeting

• Main Authors: Ying Shen (Author), Shi-jie Jin (Author), Yi-chang Chen (Author), Wen-hui Liu (Author), Yi-ming Li (Author), Wen-yi Zhao (Author), Ying-chun Xu (Author), Shu-qing Chen (Author), Wen-bin Zhao (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting single tumor antigens makes it difficult to provide sufficient tumor selectivity for T cell engagers (TCEs), leading to undesirable toxicity and even treatment failure, which is particularly serious in solid tumors. Here, we designed novel trispecific TCEs (TriTCEs) to improve the tumor se...