Cardiovascular and Renal Effects of High Salt Diet in GDNF+/- Mice with Low Nephron Number

• Main Authors: Julia Schlote (Author), Agnes Schröder (Author), Anke Dahlmann (Author), Britta Karpe (Author), Nada Cordasic (Author), Christoph Daniel (Author), Karl Friedrich Hilgers (Author), Jens Titze (Author), Kerstin Amann (Author), Kerstin Benz (Author)
• Format: Book
• Published: Karger Publishers, 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: To test the suggested association of low nephron number and later development of renal and cardiovascular disease we investigated the effects of high sodium diet in heterozygous GDNF+/- mice. Methods: Aged wild type and GDNF+/- mice were grouped together according to high sodium (HS, 4%) or lo...