Voriconazole injection may induce delayed methotrexate excretion: a case report and experimental study

• Main Authors: Daisuke Watahiki (Author), Daisuke Saito (Author), Naonori Nishida (Author), Hiroyuki Tsuri (Author), Keiko Nomura (Author), Yuichi Adachi (Author), Masato Taguchi (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background We report a case of delayed excretion of methotrexate (MTX) in a pediatric patient on high-dose MTX therapy in response to a change in the concomitant dosage of voriconazole from oral to intravenous. As the intravenous, but not the oral formulation of voriconazole includes sulfob...