Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro

• Main Authors: Takehiro Kawashiri (Author), Anna Miyagi (Author), Shiori Shimizu (Author), Nao Shigematsu (Author), Daisuke Kobayashi (Author), Takao Shimazoe (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemotherapy agents such as oxaliplatin, cisplatin, paclitaxel, and bortezomib frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this. Dimethyl fumarate (DMF) is a new oral drug for the treatment of multiple sclerosis, and has neuroprotective effec...