The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye

• Main Authors: Beatriz López-Escobar (Author), David A. Cano (Author), Anabel Rojas (Author), Beatriz de Felipe (Author), Francisco Palma (Author), José A. Sánchez-Alcázar (Author), Deborah Henderson (Author), Patricia Ybot-González (Author)
• Format: Book
• Published: The Company of Biologists, 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Embryopathies that develop as a consequence of maternal diabetes have been studied intensely in both experimental and clinical scenarios. Accordingly, hyperglycaemia has been shown to downregulate the expression of elements in the non-canonical Wnt-PCP pathway, such as the Dishevelled-associated act...