Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from <i>Bothrops pictus</i> (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

• Main Authors: Dan E. Vivas-Ruiz (Author), Paola Rosas (Author), Alex Proleón (Author), Daniel Torrejón (Author), Fanny Lazo (Author), Ana Belén Tenorio-Ricca (Author), Francisco Guajardo (Author), Cristopher Almarza (Author), Víctor Andrades (Author), Jessica Astorga (Author), Daniel Oropesa (Author), Jorge Toledo (Author), María Jesús Vera (Author), Jorge Martínez (Author), Ramiro Araya-Maturana (Author), Karen Dubois-Camacho (Author), Marcela A. Hermoso (Author), Valéria G. Alvarenga (Author), Eladio Flores Sanchez (Author), Armando Yarlequé (Author), Luciana Souza Oliveira (Author), Félix A. Urra (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

From the venom of the <i>Bothrops pictus</i> snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration. In this work, we characterize a novel P-III class snake venom metalloproteinase, called pictolysin-III (Pic-I...