Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.

• Main Authors: Hideaki Shimizu (Author), Akatsuki Saito (Author), Junko Mikuni (Author), Emi E Nakayama (Author), Hiroo Koyama (Author), Teruki Honma (Author), Mikako Shirouzu (Author), Shun-Ichi Sekine (Author), Tatsuo Shioda (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue is a mosquito-borne viral infection that has spread globally in recent years. Around half of the world's population, especially in the tropics and subtropics, is at risk of infection. Every year, 50-100 million clinical cases are reported, and more than 500,000 patients develop the sympt...