Enhancement of Aqueous Solubility and Dissolution of Celecoxib through Phosphatidylcholine-Based Dispersion Systems Solidified with Adsorbent Carriers

• Main Authors: Kanghee Jo (Author), Jae Min Cho (Author), Hyunjoo Lee (Author), Eun Kyung Kim (Author), Hong Chul Kim (Author), Hyeongmin Kim (Author), Jaehwi Lee (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property. Although PC-based dispersion formulations considerably...