Enhancement of Aqueous Solubility and Dissolution of Celecoxib through Phosphatidylcholine-Based Dispersion Systems Solidified with Adsorbent Carriers

• Κύριοι συγγραφείς: Kanghee Jo (Συγγραφέας), Jae Min Cho (Συγγραφέας), Hyunjoo Lee (Συγγραφέας), Eun Kyung Kim (Συγγραφέας), Hong Chul Kim (Συγγραφέας), Hyeongmin Kim (Συγγραφέας), Jaehwi Lee (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2018-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property. Although PC-based dispersion formulations considerably...