A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis

• Main Authors: Federico Reali (Author), Anna Fochesato (Author), Chanchala Kaddi (Author), Roberto Visintainer (Author), Shayne Watson (Author), Micha Levi (Author), Véronique Dartois (Author), Karim Azer (Author), Luca Marchetti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Understanding drug exposure at disease target sites is pivotal to profiling new drug candidates in terms of tolerability and efficacy. Such quantification is particularly tedious for anti-tuberculosis (TB) compounds as the heterogeneous pulmonary microenvironment due to the infection m...