Pharmacologic Ascorbate and DNMT Inhibitors Increase DUOX Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer

• Main Authors: Garett J. Steers (Author), Brianne R. O'Leary (Author), Juan Du (Author), Brett A. Wagner (Author), Rory S. Carroll (Author), Frederick E. Domann (Author), Prabhat C. Goswami (Author), Garry R. Buettner (Author), Joseph J. Cullen (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase (DNMT) reverses this, increasing DNA methylation and decreasing...