Effects of genetic deletion versus pharmacological blockade of the LPA1 receptor on depression-like behaviour and related brain functional activity

• Main Authors: Román Darío Moreno-Fernández (Author), Andrea Nieto-Quero (Author), Francisco Javier Gómez-Salas (Author), Jerold Chun (Author), Guillermo Estivill-Torrús (Author), Fernando Rodríguez de Fonseca (Author), Luis Javier Santín (Author), Margarita Pérez-Martín (Author), Carmen Pedraza (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Animal models of psychopathology are particularly useful for studying the neurobiology of depression and characterising the subtypes. Recently, our group was the first to identify a possible relationship between the LPA1 receptor and a mixed anxiety-depression phenotype. Specifically, maLPA1-null mi...