Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality

• Main Authors: Henri Baudhuin (Author), Janik Puttemans (Author), Heleen Hanssens (Author), Philippe Vanwolleghem (Author), Sophie Hernot (Author), Geert Raes (Author), Catarina Xavier (Author), Tony Lahoutte (Author), Pieterjan Debie (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Single domain antibodies (sdAbs) have proven to be valuable probes for molecular imaging. In order to produce such probes, one strategy is the functionalization of the reactive amine side chain of lysines with a chelator, resulting in a mixture of compounds with a different degree of conjugation. In...