Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

• Main Authors: Laura J. Lambert (Author), Anil K. Challa (Author), Aidi Niu (Author), Lihua Zhou (Author), Janusz Tucholski (Author), Maria S. Johnson (Author), Tim R. Nagy (Author), Alan W. Eberhardt (Author), Patrick N. Estep (Author), Robert A. Kesterson (Author), Jayleen M. Grams (Author)
• Format: Book
• Published: The Company of Biologists, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes to the skeleton, endocrine system, reproductive orga...