Engineering attenuated virulence of a Theileria annulata-infected macrophage.

• Main Authors: Nadia Echebli (Author), Moez Mhadhbi (Author), Marie Chaussepied (Author), Catherine Vayssettes (Author), James P Di Santo (Author), Mohamed Aziz Darghouth (Author), Gordon Langsley (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Live attenuated vaccines are used to combat tropical theileriosis in North Africa, the Middle East, India, and China. The attenuation process is empirical and occurs only after many months, sometimes years, of in vitro culture of virulent clinical isolates. During this extensive culturing, attenuate...