Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole-In Vitro and In Vivo Investigations

• Main Authors: Nibal Betari (Author), Kristoffer Sahlholm (Author), Xavier Morató (Author), Héctor Godoy-Marín (Author), Olga Jáuregui (Author), Knut Teigen (Author), Francisco Ciruela (Author), Jan Haavik (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT synthesis is catalyzed by tryptophan hydroxylase (TPH) which exists as two dist...