Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance

• Main Authors: Phillips John A (Author), Newman John (Author), Robinson Linda (Author), Geraci Mark (Author), Cogan Joy (Author), West James (Author), Lane Kirk (Author), Meyrick Barbara (Author), Loyd Jim (Author)
• Format: Book
• Published: BMC, 2008-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>While BMPR2 mutation strongly predisposes to pulmonary arterial hypertension (PAH), only 20% of mutation carriers develop clinical disease. This finding suggests that modifier genes contribute to FPAH clinical expression. Since modif...