Preclinical assessment of drug-drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist

• Main Authors: Kazutoshi Fujioka (Author), Mostafa I. Fekry (Author), Jeanne M. Rumsey (Author), Toni Steiner (Author), David Thompson (Author), Shaker A. Mousa (Author)
• Format: Book
• Published: Wiley, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The objective of the current study was to identify potential drug-drug interactions (DDIs) with the drug candidate fb‐PMT, a novel anticancer thyrointegrin αvß3 antagonist. This was accomplished by using several in vitro assays to study interactions of fb‐PMT with both cytochrome P450 (CYP)...