Optimization and Evaluation of Poly(lactide-<i>co</i>-glycolide) Nanoparticles for Enhanced Cellular Uptake and Efficacy of Paclitaxel in the Treatment of Head and Neck Cancer

• Main Authors: Mohamed Haider (Author), Amr Elsherbeny (Author), Jayalakshmi Jagal (Author), Anna Hubatová-Vacková (Author), Iman Saad Ahmed (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2020-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The particle size (PS) and encapsulation efficiency (EE%) of drug-loaded nanoparticles (NPs) may inhibit their cellular uptake and lead to possible leakage of the drug into the systemic circulation at the tumor site. In this work, ultra-high paclitaxel-loaded poly(lactide-<i>co</i>-glyco...