Synthesis of 2,7-diarylpyrazolo [1,5-a] pyrimidine derivatives with antitumor activity. Theoretical identification of targets

• Main Authors: Andrés Ballesteros-Casallas (Author), Margot Paulino (Author), Pietro Vidossich (Author), Carol Melo (Author), Elizabeth Jiménez (Author), Juan-Carlos Castillo (Author), Jaime Portilla (Author), Gian Pietro Miscione (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pyrazolo[1,5-a]pyrimidine ring system constitutes a privileged scaffold for developing drug-like compounds, whose biologic activity is dictated by the nature and position of the substituents on the heterocyclic core. Herein, we report the synthesis of nine 2,7-diarylpyrazolo[1,5-a]pyrimidine der...