Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice

• Main Authors: Yingqun Zhou (Author), Weiqi Dai (Author), Chunlei Lin (Author), Fan Wang (Author), Lei He (Author), Miao Shen (Author), Ping Chen (Author), Chenfen Wang (Author), Jie Lu (Author), Ling Xu (Author), Xuanfu Xu (Author), Chuanyong Guo (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective. Necrostatin-1 (Nec-1) inhibits receptor-interacting protein 1 (RIP1) kinase and programmed necrosis. This study was designed to examine the protective effects and mechanisms of Nec-1 in concanavalin A- (ConA-) induced hepatitis in mice. Methods. C57BL/6 mice were exposed to ConA via tail...