Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission

• Main Authors: Xiao-Ling Liang (Author), Lan Ouyang (Author), Nan-Nan Yu (Author), Zheng-Hua Sun (Author), Zi-Kang Gui (Author), Yu-Long Niu (Author), Qing-Yu He (Author), Jing Zhang (Author), Yang Wang (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Divisions at the periphery and midzone of mitochondria are two fission signatures that determine the fate of mitochondria and cells. Pharmacological induction of excessively asymmetric mitofission-associated cell death (MFAD) by switching the scission position from the mitochondrial midzone to the p...