Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K/AKT pathway

• मुख्य लेखकों: Yingzi He (लेखक), Zhiwei Zheng (लेखक), Chang Liu (लेखक), Wen Li (लेखक), Liping Zhao (लेखक), Guohui Nie (लेखक), Huawei Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to irreversible hearing loss. This study aimed to assess the potential effect of the DNA methyltransferase (DNMT) inhibitor RG108 on cisplatin-induced ototoxicity. Immunohistochemistry, apoptosis assay, and auditory...