Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

• Main Authors: Louisa Dowal (Author), Pooja Parameswaran (Author), Sarah Phat (Author), Syamala Akella (Author), Ishita Deb Majumdar (Author), Jyoti Ranjan (Author), Chahan Shah (Author), Saie Mogre (Author), Kalyani Guntur (Author), Khampaseuth Thapa (Author), Stephane Gesta (Author), Vivek K. Vishnudas (Author), Niven R. Narain (Author), Rangaprasad Sarangarajan (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptional regulation of UCP-1, PGC1α, PGC1β, and CIDEA and...