Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors

IntroductionPhosphoinositide-3-kinase (PI3K) is overexpressed in many tumors and is, thus, an ideal target for cancer treatments. Accordingly, there is an urgent need for the development of PI3K inhibitors with high potency and low toxicity.MethodsIn this study, we designed and synthesized a series...

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Egile Nagusiak: Daowei Huang (Egilea), Jixia Yang (Egilea), Qingwei Zhang (Egilea), Xiaolei Zhou (Egilea), Yanbo Wang (Egilea), Zhenhua Shang (Egilea), Jianqi Li (Egilea), Baoyin Zhang (Egilea)
Formatua: Liburua
Argitaratua: Frontiers Media S.A., 2024-10-01T00:00:00Z.
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