NF-κB Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense

• Asıl Yazarlar: Hui Li (Yazar), Wei Han (Yazar), Vasilly Polosukhin (Yazar), Fiona E. Yull (Yazar), Brahm H. Segal (Yazar), Can-Mao Xie (Yazar), Timothy S. Blackwell (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Hindawi Limited, 2013-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Introduction. Since the NF-κB pathway regulates both inflammation and host defense, it is uncertain whether interventions targeting NF-κB would be beneficial in sepsis. Based on the kinetics of the innate immune response, we postulated that selective NF-κB inhibition during a defined time period aft...