Schistosoma mansoni enhances host susceptibility to mucosal but not intravenous challenge by R5 Clade C SHIV.

• Main Authors: Nagadenahalli B Siddappa (Author), Girish Hemashettar (Author), Vivekanandan Shanmuganathan (Author), Amma A Semenya (Author), Elizabeth D Sweeney (Author), Katherine S Paul (Author), Sandra J Lee (Author), W Evan Secor (Author), Ruth M Ruprecht (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The high prevalence of HIV-1/AIDS in areas endemic for schistosomiasis and other helminthic infections has led to the hypothesis that parasites increase host susceptibility to immunodeficiency virus infection. We previously showed that rhesus macaques (RM) with active schistosomiasis were significan...