In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy

• Main Authors: Zhenbao Li (Author), Jiaojiao Zhu (Author), Yongqi Wang (Author), Mei Zhou (Author), Dan Li (Author), Shunzhe Zheng (Author), LiLi Yin (Author), Cong Luo (Author), Huicong Zhang (Author), Lu Zhong (Author), Wei Li (Author), Jian Wang (Author), Shuangying Gui (Author), Biao Cai (Author), Yongjun Wang (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic efficiency of active targeting nanoparticulate drug delivery systems (nano-DDS) is highly compromised by the plasma proteins adsorption on nanoparticles (NPs) surface, which significantly hinders cell membrane receptors to recognize the designed ligands, and provokes the off-target t...