Effects of Rivastigmine and Donepezil on Brain Acetylcholine Levels in Acetylcholinesterase-Deficient Mice

Effects of Rivastigmine and Donepezil on Brain Acetylcholine Levels in Acetylcholinesterase-Deficient Mice

Purpose. Alzheimer´s disease is characterized by a dysfunction of central cholinergic systems and is treated by inhibitors of acetylcholinesterase (AChE). This study tests the effect of two AChE inhibitors in therapeutic use, rivastigmine and donepezil, in mice that are devoid of AChE (AChE-/- mice)...

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Main Authors: Runa S. Naik (Author), Joachim Hartmann (Author), Cornelia Kiewert (Author), Ellen G. Duysen (Author), Oksana Lockridge (Author), Jochen Klein (Author)
Format: Book
Published: Frontiers Media S.A., 2009-04-01T00:00:00Z.
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