Effects of Rivastigmine and Donepezil on Brain Acetylcholine Levels in Acetylcholinesterase-Deficient Mice

• Main Authors: Runa S. Naik (Author), Joachim Hartmann (Author), Cornelia Kiewert (Author), Ellen G. Duysen (Author), Oksana Lockridge (Author), Jochen Klein (Author)
• Format: Book
• Published: Frontiers Media S.A., 2009-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Alzheimer´s disease is characterized by a dysfunction of central cholinergic systems and is treated by inhibitors of acetylcholinesterase (AChE). This study tests the effect of two AChE inhibitors in therapeutic use, rivastigmine and donepezil, in mice that are devoid of AChE (AChE-/- mice)...