Improvement of peripheral vascular impairment by a phosphodiesterase type 5 inhibitor tadalafil prevents oxaliplatin-induced peripheral neuropathy in mice

• Main Authors: Takashi Ogihara (Author), Takayuki Nakagawa (Author), Maho Hayashi (Author), Madoka Koyanagi (Author), Atsushi Yonezawa (Author), Tomohiro Omura (Author), Shunsaku Nakagawa (Author), Noriaki Kitada (Author), Satoshi Imai (Author), Kazuo Matsubara (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin, a platinum-based chemotherapeutic drug, frequently induces peripheral neuropathy. Accumulating evidences suggest a possible relationship between peripheral vascular impairment and peripheral neuropathy. In this study, we investigated the effects of vasodilators on cumulative peripheral...