Evidence for a peak shift in a humoral response to helminths: age profiles of IgE in the Shuar of Ecuador, the Tsimane of Bolivia, and the U.S. NHANES.

• Main Authors: Aaron D Blackwell (Author), Michael D Gurven (Author), Lawrence S Sugiyama (Author), Felicia C Madimenos (Author), Melissa A Liebert (Author), Melanie A Martin (Author), Hillard S Kaplan (Author), J Josh Snodgrass (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The peak shift model predicts that the age-profile of a pathogen's prevalence depends upon its transmission rate, peaking earlier in populations with higher transmission and declining as partial immunity is acquired. Helminth infections are associated with increased immunoglobulin E (IgE), whic...