Progestogens Are Metabolized by the Gut Microbiota: Implications for Colonic Drug Delivery

• Main Authors: Zoe Coombes (Author), Vipul Yadav (Author), Laura E. McCoubrey (Author), Cristina Freire (Author), Abdul W. Basit (Author), R. Steven Conlan (Author), Deyarina Gonzalez (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Following oral administration, the bioavailability of progestogens is very low and highly variable, in part due to metabolism by cytochrome P450 enzymes found in the mucosa of the small intestine. Conversely, the mucosa in the colon contains much lower levels of cytochrome P450 enzymes, thus, coloni...