Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS

• Hoofdauteurs: Tian Lan (Auteur), Ping Fang (Auteur), Xuemei Ye (Auteur), Xia Lan (Auteur), Ren-ai Xu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Context Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin. Objective To investigate the effect of shikonin on ambrisentan metabolism in vivo and in vitro. Materials and methods This study developed an ultra-pe...