One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products

• Main Authors: Mercedes Prieto-Escolar (Author), Juan J. Torrado (Author), Covadonga Álvarez (Author), Alejandro Ruiz-Picazo (Author), Marta Simón-Vázquez (Author), Carlos Govantes (Author), Jesús Frias (Author), Alfredo García-Arieta (Author), Isabel Gonzalez-Alvarez (Author), Marival Bermejo (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Montelukast is a weak acid drug characterized by its low solubility in the range of pH 1.2 to 4.5, which may lead to dissolution-limited absorption. The aim of this paper is to develop an in vivo predictive dissolution method for montelukast and to check its performance by establishing a level-A in...