The E3 ligase TRIM56 is a host restriction factor of Zika virus and depends on its RNA-binding activity but not miRNA regulation, for antiviral function.

• Autores principales: Darong Yang (Autor), Nan L Li (Autor), Dahai Wei (Autor), Baoming Liu (Autor), Fang Guo (Autor), Husni Elbahesh (Autor), Yunzhi Zhang (Autor), Zhi Zhou (Autor), Guo-Yun Chen (Autor), Kui Li (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2019-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Infection by Zika virus (ZIKV) is linked to microcephaly and other neurological disorders, posing a significant health threat. Innate immunity is the first line of defense against invading pathogens, but relatively little is understood regarding host intrinsic mechanisms that guard against ZIKV. Her...