The E3 ligase TRIM56 is a host restriction factor of Zika virus and depends on its RNA-binding activity but not miRNA regulation, for antiviral function.

• Main Authors: Darong Yang (Author), Nan L Li (Author), Dahai Wei (Author), Baoming Liu (Author), Fang Guo (Author), Husni Elbahesh (Author), Yunzhi Zhang (Author), Zhi Zhou (Author), Guo-Yun Chen (Author), Kui Li (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection by Zika virus (ZIKV) is linked to microcephaly and other neurological disorders, posing a significant health threat. Innate immunity is the first line of defense against invading pathogens, but relatively little is understood regarding host intrinsic mechanisms that guard against ZIKV. Her...