A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses

• Main Authors: Wenjie Zhai (Author), Xiuman Zhou (Author), Hongfei Wang (Author), Wanqiong Li (Author), Guanyu Chen (Author), Xinghua Sui (Author), Guodong Li (Author), Yuanming Qi (Author), Yanfeng Gao (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PD-1 and CTLA-4 antibodies offer great hope for cancer immunotherapy. However, many patients are incapable of responding to PD-1 and CTLA-4 blockade and show low response rates due to insufficient immune activation. The combination of checkpoint blockers has been proposed to increase the response ra...