T-cell receptor and K-deleting recombination excision circles in newborn screening of T- and B-cell defects: review of the literature and future challenges

• Main Authors: Marco Chiarini (Author), Cinzia Zanotti (Author), Federico Serana (Author), Alessandra Sottini (Author), Diego Bertoli (Author), Luigi Caimi (Author), Luisa Imberti (Author)
• Format: Book
• Published: SAGE Publishing, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since its introduction as a public health programme in the United States in the early 1960s, newborn blood screening (NBS) has evolved from the detection of phenylalanine levels on filter paper to the application of DNA-based technologies to identify T-cell lymphopenia in infants with severe combine...