Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice

• Main Authors: Yu-Hui Gu (Author), Kai-Wen Ren (Author), Yu Wang (Author), Shi-Hao Wang (Author), Xiao-Hong Yu (Author), Li-Wen Xu (Author), Hui-Hua Li (Author), Hai-Lian Bi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypertension is one of the common causes of pathological cardiac hypertrophy and a major risk for morbidity and mortality of cardiovascular diseases worldwide. Ubiquitin-Specific Protease 7 (USP7), the first identified deubiquitinating enzymes, participated in a variety of biological processes, such...