Biodistribution of the saponin-based adjuvant Matrix-M™ following intramuscular injection in mice

• Main Authors: Cecilia Carnrot (Author), Berit Carow (Author), Anna-Karin E. Palm (Author), Eray Akpinar (Author), Per-Henrik Helgesson (Author), Ingrid Lekberg Osterman (Author), Emelie Bringeland (Author), Bryant Foreman (Author), Nita Patel (Author), Johan Bankefors (Author), Louis Fries (Author), Linda Stertman (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel adjuvants are extensively utilized in the development of safe and effective vaccines against emerging pathogens. Matrix-M™ adjuvant is a saponin-based adjuvant used in several active clinical development programs and in widespread use in the COVID-19 vaccine NVX-CoV2373. Here, we conducted a b...