Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein

• Main Authors: Manar I. Nagy (Author), Khaled M. Darwish (Author), Safaa M. Kishk (Author), Mohamed A. Tantawy (Author), Ali M. Nasr (Author), Mona Qushawy (Author), Shady A. Swidan (Author), Samia M. Mostafa (Author), Ismail Salama (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling is considered a promising strategy for cancer treatment. Within the current work, we aimed to design and synthesize a new series of benzimidaz...