Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells.

• Main Authors: Ross A Paveley (Author), Sarah A Aynsley (Author), Peter C Cook (Author), Joseph D Turner (Author), Adrian P Mountford (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection of the mammalian host by the parasitic helminth Schistosoma mansoni is accompanied by the release of excretory/secretory molecules (ES) from cercariae which aid penetration of the skin. These ES molecules are potent stimulants of innate immune cells leading to activation of acquired immuni...