Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis

• Main Authors: Yanliang Yang (Author), Lingli Xie (Author), Yanjun Zhong (Author), Xiaoli Zhong (Author), Ran Meng (Author), Qianqian Xue (Author), Fang Liang (Author), Kai Zhao (Author), Yiting Tang (Author)
• Format: Book
• Published: Karger Publishers, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Double-stranded RNA dependent kinase R (PKR) is originally identified as an intracellular sensor of viral infection, but its role in bacterial infection remains largely unknown. Here we report that PKR was an important regulator of antibacterial immunity in sepsis. Genetic deletion of PKR or pharmac...