Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor

• Main Authors: Hui-Jing Wang (Author), Han-Xin Gu (Author), Niels Eijkelkamp (Author), Cobi J. Heijnen (Author), Annemieke Kavelaars (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: We recently identified the balance between the level of G protein coupled receptor kinase 2 (GRK2) and Epac1 in nociceptors as a key factor in the transition from acute to chronic pain that occurs in mice 'primed' by an inflammatory stimulus. Here, we examined the contribution...