A Novel Adenoviral Hybrid-vector System Carrying a Plasmid Replicon for Safe and Efficient Cell and Gene Therapeutic Applications

• Main Authors: Richard Voigtlander (Author), Rudolf Haase (Author), Martin Mück-Hausl (Author), Wenli Zhang (Author), Philip Boehme (Author), Hans-Joachim Lipps (Author), Eric Schulz (Author), Armin Baiker (Author), Anja Ehrhardt (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In dividing cells, the two aims a gene therapeutic approach should accomplish are efficient nuclear delivery and retention of therapeutic DNA. For stable transgene expression, therapeutic DNA can either be maintained by somatic integration or episomal persistence of which the latter approach would d...