Predictability of human exposure by human‐CYP3A4‐transgenic mouse models: A meta‐analysis

• मुख्य लेखकों: David Damoiseaux (लेखक), Alfred H. Schinkel (लेखक), Jos H. Beijnen (लेखक), Alwin D. R. Huitema (लेखक), Thomas P. C. Dorlo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract First‐in‐human dose predictions are primarily based on no‐observed‐adverse‐effect levels in animal studies. Predictions from these animal models are only as effective as their ability to predict human results. To narrow the gap between human and animals, researchers have, among other things...